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Dimethylaminoethanol (DMAE) is a naturally occurring organic compound with a list of alias’, including N, N-dimethyl-2-aminoethanol, and Deanol to name a few.   It is a relative to choline with a similar chemical structure minus one methyl group from the nitrogen, DMAE can maneuver the blood-brain barrier more effectively than choline.  Once the liver processes DMAE, a charged choline molecule is produced but has the inability to cross the blood-brain barrier.   It has been argued that DMAE is linked as a precursor to the synthesis of acetylcholine, a neurotransmitter responsible for healthy nerve signaling.  Because of its efficiency through cognitive channels, methylation of DMAE to produce choline directly at the site of use has proven to be more valuable than choline alone.


DMAE is naturally produced in the brain of humans, but in small amounts.  Fish, particularly salmon and sardines, are highly concentrated in this compound.  The overall effects and benefits provided by this substance are extensive and of many.  The most common are those pertaining to overall health of the brain and cognitive behaviors.  It enhances brain activity primarily from the effective transport exhibited through the blood-brain barrier, thus aiding in brain function and response with the creation of neurotransmitters.   DMAE has shown to increase cognitive functioning related to Attention Deficit Disorder, and improves behaviors such as aggression and apathy.  Mental improvements were observed in a study that included students supplementing with DMAE in a 6 week trial.  Concentration, learning and memory functions improved as a result.


Individuals taking DMAE demonstrated an increase in energy, particularly a stimulation by the central nervous system. This ties into a decline in sufficient sleep time with the addition of improved quality of sleep.  DMAE also provides antioxidant effects to reduce the formation of free radicals by acting as a reducing agent upon on-going oxidation reactions in cells.  As a result, maintenance of healthy genetic material and reduced DNA damage is obtained by using DMAE supplements.


Current studies are researching claims supporting DMAE’s ability to prevent cardiovascular conditions and degenerative diseases.  More recently, DMAE has been marketed to enhance healthy skin and fight the signs for aging.  Topical formulas that include this as an ingredient aid to reduce the appearance of wrinkles and age spots by eliminating the production of arachidonic acid, which is the culprit leading to wrinkles.


The recommended daily dosage is 100mg for adults.  Children, pregnant women, and mothers nursing should consult with a medical physician prior to supplementing with DMAE.


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