Dr. Kumar Pati, USA


Arginine alpha-ketoglutarate (AAKG) is a salt composed of the amino acid Arginine and Alpha-Ketoglutaric Acid.  It has been marketed as a body building supplement as an advanced form of Arginine.  Arginine is a popular supplement used widely by bodybuilders and athletes to accelerate muscle growth, increase strength and endurance.  This amino acid is also involved in protein synthesis, by acting as an active substance.  Alpha-ketoglutarate is also an important biological compound.   It helps the body to create usable energy from carbohydrates, fats and protein.


In addition to the benefits provided by Arginine, together with Alpha-Ketoglutaric Acid, AAKG adds to the effect of quick recovery after physical exercise as well as improves sexual performance.  Alpha-Ketoglutarate helps to improve the delivery of Arginine throughout the body.  It is widely used as one of the most important nitrogen (NO) transporters that positively affect metabolic pathways.  In short, the coupling of Arginine to Alpha-Ketoglutarate helps control hormones, builds muscles and is a part of the amino acid group.

L-Arginine Alpha-Ketoglutarate is commonly used by bodybuilders, athletes and regular gym users who want to gain muscle mass and increase strength, as well as sexual vigor.  L-Arginine Alpha-Ketoglutarate acts as a stimulant to nitric oxide production in the body.  Nitric oxide is an important element used in directing and ordering a complex array of activities, which include but are not limited to blood flow regulation, muscle contraction, and muscle growth.  Unfortunately, nitric oxide is not readily available and cannot simply be bought at drug stores.   Therefore, people use L-Arginine Alpha-Ketoglutarate, a natural, non-medicated method for building nitric oxide in the human body.


L-Arginine Alpha-Ketoglutarate is a dietary supplement sold in a number of forms:  tablets, pills, or powder.   The suggested dosage is 2 or 3 tablets once or twice a day on an empty stomach, preferably int eh morning and at least 30 minutes before workouts.  When using AAKG powder, the recommended dose will range anywhere from 1500 and 3500 mg of powder supplement.  It is also recommended to use AAKG powder with a combination of creatine and other amino acids.  You can also increase the AAKG dosage to 1500 mg 3 times a day and use creatine-based products.  This will more effectively assist in muscle growth.  To avoid possible side effects, this substance is not recommended for continuous, high-level use for more than 60 days and you should not consume powdered NO drinks, which will contain many of these ingredients.

Depending on your body’s needs, AAKG dosage may vary from 2 to15 gramsper day.  Bodybuilders and athletes usually take ½ a tablespoon AAKG powder, which equivalents to approximately4 grams, 3 times a day, thus the total recommended dosage can be as high as12 gramsof powder.  When taking AAKG for general and cardiovascular health, consider taking 1 teaspoon (approximately1.33 grams) 2 to 3 times a day with the total amount ranging between 2 and4 gramsa day.

u�l mn@�@i� necessary for some patients, appropriate dosage should be determined with the consultation of a qualified physician.  Alanine is generally considered to be safe for most people.  However, people with kidney or liver disease should not consume high intakes of amino acids without consulting a healthcare professional.  Isolated alanine supplements are not recommended.






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