L-HISTIDINE, A Synthesized Protein Dr. Kumar Pati, USA

L-HISTIDINE, A Synthesized Protein





L-Histidine is an amino acid found in the proteins of all life forms.  Although most L-Histidine is found in proteins, a small amount of free L-Histidine does exist in plants and fermented foods.  The naturally occurring dipeptides found in muscle, carnosine and anserine, are both comprised of L-Histidine and beta-alanine.  L-Histidine is essential, playing a significant role in the growth and repair of tissues.  It is involved in the maintenance of myelin sheath, the surrounding layer of nerve cells which serves as protection.  It is required for the production of red and white blood cells, while balancing blood pressure levels in the body.  In addition, L-Histidine protects the body against radiation damage, along with aiding in the removal of harmful heavy metals.  Histamines are important chemicals used to maintain a healthy immune system.  They too are derived from L-Histidine.


L-Histidine is one of 10 essential amino acids required by infants.  However, the requirements for adults has not yet been confirmed to be essential.  At the very least, it is a conditional essential amino acid for adults.  That is, even though L-Histidine is synthesized in adult human tissues, sufficient quantities may not be made to meet the physiological requirements imposed by certain stress or disease situations.  L-Histidine may be indicated for use by patients with rheumatoid arthritis.


L-Histidine is absorbed from the small intestine via an active transport mechanism requiring the presence of sodium.  From the small intestine, L-Histidine is transported to the liver by means of the portal circulation, where some is metabolized and form whence some enters the systemic circulation to be distributed to various tissues in the body.


L-Histidine can be obtained in a variety of foods, including beans, brewer’s yeast, brown rice bran, caseinate, dairy products, eggs, fish, lactalbumin, legumes, meat, nuts, seafood, seeds, soy, whey, whole grains.  Dairy, meat and poultry, and fish are all good sources of Histidine.


The supplemental effects from L-Histidine are not entirely clear, there may be some immunomodulatory symptoms as well as antioxidant activity that result from taking L-Histidine supplements.  There are no known signs of toxicity from L-Histidine.  Lare doses of L-Histidine can cause premature ejaculation, reduces levels of zinc and possibly trigger an allergic or asthmatic reaction (due to increases in histamine).  Long-term supplementation with L-Histidine may give rise to a copper deficiency and raise blood cholesterol levels.  L-Histidine is generally well-tolerated.  Children, Pregnant women and nursing mothers should avoid L-Histidine supplements.  Use of L-Histidine supplements must be done under medical supervision.


Tablets and capsules are typically available in 500 milligram to 100 milligram dosages.  Dosages have ranged from 500 milligrams to4.5 gramsdaily.  However, most people do not need to supplement L-Histidine.  Most studies of L-Histidine have used between 1 and8 gramsper day.



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