Methylcobalamin is a form of vitamin B12 Dr. Kumar Pati, USA

Methylcobalamin is a form of vitamin B12

Dr. Kumar Pati, USA


that can also be found written as MeCB1 or MeB12.   It is one of four cobalamin compounds that the human body is able to metabolize.  A cobalamin compound contains a central cobalt ion, with one of four particular groups attached to its upper ligand.  These ligands can either be a cyanide, a hydroxide, an adenosine, or a methyl group.


Vitamin B12 is a water-soluble vitamin necessary for energy production.  It is an important component involved in the production of myelin, the fatty substance that forms a protective sheath around nerves, to conduct proper nervous system functions.  Methylcobalamin vital for the maintenance of optimal cognitive abilities;  it is responsible for the production of acetylcholine, a neurotransmitter that helps with memory and learning.  Other functions offered by this vitamin include the synthesis of red blood cells, and the production of genetic material such as DNA and RNA.  It can assist in relieving depression by enhancing the body’s energy levels.


Vitamin B12 is essentially obtained from a source of bacteria.  This can be obtained directly from the dut of animals as the bacteria are often found inhabiting a section of the gut posterior of where B12 is absorbed.  Indirect sources include fish, shellfish, eggs, milk products, and meats, especially liver.  Vegans are required to obtain sources of vitamin B12 through B12-fortified foods, or dietary supplements..


In a recent study, subjects taking methylcobalamin experienced improvement in sleep quality and increased daytime alertness and concentration.   In some cases they also reported improved mood.  Much of the benefit appears to be a result of methylcobalamin’s influence on melatonin secretion and resetting the biological clock.  Specifically, methylcobalamin causes a significant decrease in daytime melatonin levels while increasing nighttime levels.


Methylcobalamin makes adrenaline from norepinephrine, and melatonin from serotonin.   It is crucial for the transcription of DNA and other entities.  The methyl group from this B12 form is required from the conversion of harmful homocysteine into beneficial methionine which acts as an antioxidant.  The cardiac system is protected as a result of this reaction.  The use of methylcobalamin or other forms of vitamin B12 to treat B12 deficiencies or other medical conditions requires medical supervision.  It should not be used in those with leber’s opticatrophy.


The general daily dosage of vitamin B12 falls between 3 to 30 micrograms.  Although higher doses have been consumed, the Food and Nutrition Board advises that individuals older than 50 years of age to consume foods fortified with B12 in order to meet the RDA (2.4 micrograms daily).  A typical dose of vitamin B12 as a nutritional supplement used by pregnant women and nursing mothers is 12 micrograms daily.   Administration of doses of vitamin B12 greater than 10 micrograms daily may produce a hematological response in those with anemia secondary to folate deficiency.


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: