L-Methionine is a protein amino acid.  It is classified as an essential amino acid for humans and therefore is a requirement in our everyday diet.  L-Methionine is also known to be glycogenic amino acid and is involved in the formation of d-glucose and glycogen.  It is an important sulfur-containing amino acids with a molecular structure that is insoluble in water.


According to the Food and Agriculture Organization of the United States (FAO) and World Health Organization (WHO) the recommended intake for L-Methionine is 13 mg daily for every kilogram of weight, which equivalents to about one gram daily in adults.  However, the actual daily intake is higher due to its rich source is foods.  L-Methionine is principally derived from dietary proteins which include cheeses, eggs, fish, meat and poultry.   It can also be found in fruits and vegetables, though these sources are less abundant in this amino.


L-Methionine is contraindicated in those with the genetic disorder homocystinuria, as well as those who show hypersensitivity to any component of methionine-containing products.  Endometriosis, a condition in which patches of endometrial tissue from the uterine lining grow outside the uterus, has a proposed treatment when L-Methionine is paired with lipotropic compounds.  In addition, L-Methionine is an especially important nutrient beneficial for those suffering from estrogen dominance, where the amount of estrogen in the body is excessively high in comparison to its opposing hormone called progesterone.  The nutrient is believed to help expedite the removal of excess estrogen from the liver.


L-Methionine is both an antioxidant and lipotrope, meaning it helps to remove fat from the liver.  Methionine contributes to the hydrophobicity of a protein.   Methionine controls the level of beneficial sulfur-containing compounds in the body.  These sulfur containing compounds are in turn vital for defending against toxic compounds like heavy metals in the liver.  Methionine helps reduce histamine levels, which are amino acids that control dilation of blood vessels and influence brain function.


A clinical trial conducting research on healthy individuals supplementing with various doses of L-Methionine found results as follows:  Healthy adults taking8 gramsof L-Methionine daily for days weekly were found to have reduced serum folate levels and leucocytosis.  Healthy adults taking13.9 gramsof L-Methionine daily for five days a week were found to have changes in serum pH and potassium and increased urinary calcium excretion.


Dietrary supplementation with L-Methionine was found to decrease glycine levels when given to healthy women ona low-protein diet.  High L-Methionine intake in a diet high in salt and nitrites/nitrates may increase the rish of stomach cancer.  L-Methionine supplements should be avoided by pregnant women and nursing mothers unless they are prescribed by a physician.  It should also be avoided by those with neoplastic disease.  Individuals with elevated homocysteine levels, and taken with caution for those with coronary heart disease.  Doses of 250 mg L-methionine daily are generally well tolerated.  Higher doses may cause nausea, vomiting and headaches.



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